Generic Switching and Non-Persistence among Medicine Users: A Combined Population-Based Questionnaire and Register Study
نویسندگان
چکیده
BACKGROUND Generic substitution means that one medicinal product is replaced by another product containing the same active substance. It is strictly regulated with respect to its bioequivalence, and all products must have undergone appropriate studies. Although generic substitution is widely implemented, it still remains to be answered how generic switch influences persistence to long-term treatment, and if it is modified by patients' concerns about medicine and views on generic medicine. This study focuses on users of antidepressants and antiepileptics, and their experience of generic switching. METHODS The study was an observational cohort study. By use of a prescription database, we identified patients who had redeemed prescriptions on generically substitutable drugs, and a questionnaire was mailed to them. We analyzed predictors of discontinuation in relation to generic switch and patients' attitudes towards generic medicines and concerns about their medicine. RESULTS Patients who experience their first-time switch of a specific drug were at higher risk of non-persistence, Hazard Ratio 2.98, 95% CI (1.81;4.89) versus those who have never switched, and 35.7% became non-persistent during the first year of follow-up. Generic switching did not influence persistence considerably in those having previous experience with generic switching of the specific drug. Stratified analyses on users of antidepressants and antiepileptics underpin the results, showing higher risk of non-persistence for first-time switchers for both drug categories. CONCLUSION In conclusion, patients who are first-time switchers of a specific drug were at higher risk of non-persistence compared to never switchers and those having experienced previous generic switching.
منابع مشابه
The effect of generic switching on concerns about medicine and non-persistence among Danish adults in a general practice setting.
BACKGROUND Generic substitution means that one medicinal product is replaced by another product containing the same active substance. Generic substitution has existed in Denmark since 1991, and pharmacies are obliged to substitute a generic version of a medication, unless the general practitioner (GP) has explicitly stated that it should not be done, or the patient insists on having the more ex...
متن کاملComparison of personality characteristics and loneliness of users and non-users of social networks among Lali Payame Noor university students
The Introduction : Networking sites like Facebook or XING for instance provide individuals not only a technical platform to get together, but they enable users to articulate and make visible their own social networks. The purpose of this study was to comparise personality characteristics and loneliness of users and non-users of social networks among Lali Payam e Noor university students. Method...
متن کاملComparative effect of exercise therapy and ergonomics methods based on a virtual space on computer users with neck pain
Neck pain is one of the most common injuries at computer environments. This study aimed to compare the effect of exercise rehabilitation and ergonomic methods based on virtual space over 12 weeks on computer users with neck pain. The statistical population of this study included 150 patients with neck pain. This study was quasi experimental and participants were randomly assigned into two ergon...
متن کاملMisalignment on the Persistence of Inflation in Iran
The purpose of this study is to investigate the impact of exchange rate misalignment on inflation persistence. For this purpose, Vector Auto Regression method and Markov Switching model is used for quarterly data during 1989:4 -2014:3. The results show that, the impact of liquidity growth and exchange rate misalignment on inflation persistence is positive. On the other hand, GDP growth has a ne...
متن کاملComparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study
We compared persistence of antiepileptic drugs (AEDs) including carbamazepine, oxcarbazepine, gabapentin, lamotrigine, topiramate, valproic acid, and phenytoin in an Asian population with epilepsy.A retrospective cohort study was conducted by analyzing Taiwan's National Health Insurance Research Database (NHIRD). Adult epilepsy patients newly prescribed with AEDs between 2005 and 2009 were incl...
متن کامل